Yazar "Öznam, Kadir" için listeleme
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Are we using slow-acting symptomatic chondroprotective drugs conscious enough?
Gümüştaş, Seyit Ali; Öznam, Kadir; Mutlu, Çağrı Ata; Kaya, Yasin Emre; Yılmaz, İbrahim; İşyar, Mehmet; Yıldırım Güzelant, Aliye; Güler, Olcay; Akkaya, Semih; Mahiroğulları, Mahir (Bentham Open, 2017)Background: Osteochondral injuries constitute an entity that is widespread and can be seen in patients of all ages. Actual treatment modalities aim to relieve pain, obtain full range of movement of the joint, and improve ... -
Assessing the negative impact of phenyl alkanoic acid derivative, a frequently prescribed drug for the suppression of pain and inflammation, on the differentiation and proliferation of chondrocytes
Gümüştaş, Seyit Ali; Yılmaz, İbrahim; İşyar, Mehmet; Şirin Yaşar, Duygu; Batmaz, Ahmet Güray; Uğraş, Ali Akın; Öznam, Kadir; Çiftçi, Zafer; Mahiroğulları, Mahir (BMC, 2016)Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed to relieve pain and inflammation. These NSAIDs have also analgesic effects and can be administered via oral, injectable, and topical ... -
The association between different molecular weights of hyaluronic acid and CHAD, HIF-1 alpha, COL2A1 expression in chondrocyte cultures
Yaşar Şirin, Duygu; Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Akyuva, Yener; Kaya, Yasin Emre; Öznam, Kadir; Akkaya, Nuray; Güler, Olcay; Akkaya, Semih; Mahiroğulları, Mahir (Spandidos Publications Ltd, 2018)The aim of the present study was to investigate the effects of three different formulations of hyaluronic acid (HA): Low molecular weight (MW) Sinovial One((R)), medium MW Viscoplus((R)) and high MW Durolane((R)), on ... -
Do endocrinopathies cause changes in transverse carpal ligament thickness and carpal tunnel area in carpal tunnel syndrome?
Karaarslan, Numan; Şimşek, Abdullah Talha; Öznam, Kadir; Bülbül, Ahmet Murat (Galenos Publishing House, 2020)Objective: The purpose of this study was to investigate the effect of transverse carpal ligament (TCL) thickness and the size of carpal tunnel area on clinical findings and electrophysiological changes through the wrist ... -
Does leukocyte-poor or leukocyte-rich platelet-rich plasma applied with biopolymers have superiority to conventional platelet-rich plasma applications on chondrocyte proliferation?
Yaşar Şirin, Duygu; Yılmaz, İbrahim; İşyar, Mehmet; Öznam, Kadir; Mahiroğulları, Mahir (Turkish Joint Diseases Foundation, 2017)Objectives: This study aims to investigate the possible effects of leukocyte concentration in the content of platelet-rich plasma (PRP) and the administration of PRP using a drug delivery system on chondrocyte proliferation ... -
Does oseltamivir protect human chondrocyte and nucleus pulposus cells from degeneration by inhibiting senescence and proinflammation mediated by the NLRP3 inflammasome and NF-κB?
Yılmaz, İbrahim; Akalan, Hande; Öznam, Kadir; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Verduci Editore s.r.l, 2022)OBJECTIVE: Recent drug design studies suggest that inflammation is among the most important factors in the development of both intervertebral disc (IVD) degeneration (IVDD) and osteoarthritis (OA) due to cartilage damage. ... -
Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue
Karaarslan, Numan; Batmaz, Ahmet Güray; Yılmaz, İbrahim; Özbek, Hanefi; Çalışkan, Tezcan; Yaşar Şirin, Duygu; Kaplan, Necati; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)Non-steroidal anti-inflammatory drugs (NSAIDs) that are applied through oral, injectable or topical routes have been widely used in painful and inflammatory musculoskeletal diseases. The current study aimed to determine ... -
Effectiveness of iloprost in the treatment of bone marrow edema
Tosun, Hacı Bayram; Uludağ, Abuzer; Demir, Şükrü; Serbest, Sancar; Yaşar, Mehmet Mete; Öznam, Kadir (Cureus Inc, 2020)Background and objectiveBone marrow edema (BME) is a rare condition caused by insufficient osseous blood supply and may result in severe pain that has adverse effects on patients' life. To date, various conservative ... -
The effects of press-fit technique combined with tranexamic acid on duration of surgery and intraoperative blood loss in primary total hip arthroplasty
Çataltepe, Aziz; Öznam, Kadir (Cureus, Inc., 2022)Background: Prolonged operative time and blood loss may affect the success rate in total hip arthroplasty (THA). The aim of the current study was to evaluate the effects of the press-fit (PF) technique without screws ... -
Femur neck fracture in young adults, is it really an urgent surgery indication: Retrospective clinical study
Gümüştaş, Seyit Ali; Tosun, Hacı Bayram; İşyar, Mehmet; Serbest, Sancar; Öznam, Kadir; Bulut, Güven (African Field Epidemiology Network-Afenet, 2018)Introduction: Femur neck fracture comprises a significant part of intracapsular femur fracture in the intracapsular area of proximal femur and it is mostly seen in elder people. However, these kinds of fractures may be ... -
Iopromide- and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes
Öznam, Kadir; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Kaya, Yasin Emre; İşyar, Mehmet; Gümüştaş, Seyit Ali; Özbek, Hanefi; Akkaya, Semih; Kayhan, Arda; Mahiroğulları, Mahir (BMC, 2017)Background: Magnetic resonance arthrography, a procedure through which contrast agents containing gadolinium and/or iopromide are administered intra-articularly, has become a useful tool in musculoskeletal diagnosis. ... -
Is implant washing and wound irrigation with rifampicin effective for preventing surgical site infections in lumbar instrumentation?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Öznam, Kadir; Ateş, Özkan; Erdem, İlknur (Turkish Neurosurgical Society, 2018)AIM: To determine whether the washing of implants and autogenous bone grafts with rifampicin, and the irrigation of the surgical field using diluted rifampicin, have any significant effect on the prevention of spinal implant ... -
Is there a treatment protocol in which platelet-rich plasma is effective?
Yılmaz, İbrahim; Akkaya, Semih; İşyar, Mehmet; Batmaz, Ahmet Güray; Güler, Olcay; Öznam, Kadir; Uğras, Akın; Mahiroğulları, Mahir (Elsevier Science Bv, 2016)Aim: We aimed to reveal whether there are prospective suggestions for effective and standard platelet-rich plasma applications. Methods: We searched for clinical trials and traced all the references of incorporated documents. ... -
Ortopedik cerrah tirotoksik fırtınaya yakalanmamak için ne yapmalı?
Ekiz Bilir, Betül; Bilir, Bülent; İşyar, Mehmet; Tonbul, Ayşe Tuba; Öznam, Kadir; Yılmaz, İbrahim; Çakmak, Selami (2016)Amaç: Non iyonik kontrast maddeler gibi iyot içeren preparatların kullanıldığı görüntüleme tetkiklerinde, kas protein yıkımına neden olan travmalarda, kosta kırıklarında, pürülan artrit gibi enfektif olgularda, kalça ... -
Pregabalin treatment for neuropathic pain may damage intervertebral disc tissue
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaplan, Necati; Kaya, Yasin Emre; Akyuva, Yener; Gürbüz, Mehmet Sabri; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)The aim of the present study was to determine whether pharmaceutical preparations with pregabalin (PGB) as an active ingredient, which are widely prescribed by clinicians, exert toxic effects on human primary nucleus ... -
Systematic evaluation of drug-loaded hydrogels for application in osteosarcoma treatment
Gümüştaş, Seyit Ali; İşyar, Mehmet; Topuk, Savaş; Yılmaz, İbrahim; Öznam, Kadir; Onay, Tolga; Ofluoğlu, Önder; Mahiroğulları, Mahir (Bentham Science Publ Ltd, 2016)This is a literature review of studies focusing on the preparation of hydrogels for use as oncological drug delivery systems in the treatment of osteosarcoma (OS). The databases of the US National Library of Medicine ...